Membrane-spanning 4-domains subfamily A member 4A (MS4A4A)
Homo sapiens — UniProt Q96JQ5
Data last refreshed: (UniProt release unknown)
Key facts
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) is a protein from Homo sapiens identified by UniProt accession Q96JQ5, 239 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.
- UniProt accession: Q96JQ5; gene symbol MS4A4A.
- Organism: Homo sapiens.
- Length: 239 amino acids.
- Top disease associations (Open Targets): blood protein measurement, heel bone mineral density and soluble triggering receptor expressed on myeloid cells 2 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 4A |
|---|---|
| UniProt accession | Q96JQ5 |
| Gene | MS4A4A |
| Organism | Homo sapiens |
| Length | 239 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (130)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.29
- heel bone mineral density · score 0.23
- soluble triggering receptor expressed on myeloid cells 2 measurement · score 0.23
- neutrophil count · score 0.19
- bone quantitative ultrasound measurement · score 0.19
- hypertension · score 0.19
- white matter hyperintensity measurement · score 0.19
- factor VII measurement · score 0.18
- Alzheimer disease · score 0.16
- lymphocyte percentage of leukocytes · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96JQ5-F1 | alphafold | PREDICTED | 73.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96JQ5.
Amino-acid sequence (239 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MS4A4A?
The strongest Open Targets associations for MS4A4A are blood protein measurement, heel bone mineral density, soluble triggering receptor expressed on myeloid cells 2 measurement, neutrophil count and bone quantitative ultrasound measurement.
How long is the MS4A4A protein?
The Homo sapiens MS4A4A protein (UniProt Q96JQ5) is 239 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96JQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96JQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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