PDZ and LIM domain protein 2 (PDLIM2)
Homo sapiens — UniProt Q96JY6
Data last refreshed: (UniProt release unknown)
Key facts
PDZ and LIM domain protein 2 (PDLIM2) is a protein from Homo sapiens identified by UniProt accession Q96JY6, 352 residues long. MolForge cross-references it against 0 known binders and 162 disease associations.
- UniProt accession: Q96JY6; gene symbol PDLIM2.
- Organism: Homo sapiens.
- Length: 352 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PDZ and LIM domain protein 2 |
|---|---|
| UniProt accession | Q96JY6 |
| Gene | PDLIM2 |
| Organism | Homo sapiens |
| Length | 352 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (162)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- platelet count · score 0.40
- platelet crit · score 0.34
- leukocyte count · score 0.32
- C-reactive protein measurement · score 0.18
- diastolic blood pressure · score 0.13
- lymphocyte count · score 0.11
- neoplasm · score 0.11
- cancer · score 0.09
- serum non-albumin protein measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96JY6-F1 | alphafold | PREDICTED | 67.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96JY6.
Amino-acid sequence (352 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDLIM2?
The strongest Open Targets associations for PDLIM2 are neurodegenerative disease, platelet count, platelet crit, leukocyte count and C-reactive protein measurement.
How long is the PDLIM2 protein?
The Homo sapiens PDLIM2 protein (UniProt Q96JY6) is 352 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96JY6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96JY6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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