Abscission/NoCut checkpoint regulator (ZFYVE19)
Homo sapiens — UniProt Q96K21
Data last refreshed: (UniProt release unknown)
Key facts
Abscission/NoCut checkpoint regulator (ZFYVE19) is a protein from Homo sapiens identified by UniProt accession Q96K21, 471 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q96K21; gene symbol ZFYVE19.
- Organism: Homo sapiens.
- Length: 471 amino acids.
- Top disease associations (Open Targets): cholestasis, progressive familial intrahepatic, 9, neurodegenerative disease and MODY.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Abscission/NoCut checkpoint regulator |
|---|---|
| UniProt accession | Q96K21 |
| Gene | ZFYVE19 |
| Organism | Homo sapiens |
| Length | 471 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- cholestasis, progressive familial intrahepatic, 9 · score 0.72
- neurodegenerative disease · score 0.28
- MODY · score 0.04
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.03
- ciliopathy · score 0.01
- systemic juvenile idiopathic arthritis · score 0.01
- Cholestasis · score 0.01
- glycogen storage disease VI · score 0.01
- mucous membrane pemphigoid · score 0.00
- progressive familial intrahepatic cholestasis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96K21-F1 | alphafold | PREDICTED | 69.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96K21.
Amino-acid sequence (471 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZFYVE19?
The strongest Open Targets associations for ZFYVE19 are cholestasis, progressive familial intrahepatic, 9, neurodegenerative disease, MODY, Glycogen storage disease due to hepatic glycogen synthase deficiency and ciliopathy.
How long is the ZFYVE19 protein?
The Homo sapiens ZFYVE19 protein (UniProt Q96K21) is 471 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96K21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96K21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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