Multiple epidermal growth factor-like domains protein 10 (MEGF10)
Homo sapiens — UniProt Q96KG7
Data last refreshed: (UniProt release unknown)
Key facts
Multiple epidermal growth factor-like domains protein 10 (MEGF10) is a protein from Homo sapiens identified by UniProt accession Q96KG7, 1140 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q96KG7; gene symbol MEGF10.
- Organism: Homo sapiens.
- Length: 1140 amino acids.
- Top disease associations (Open Targets): MEGF10-related myopathy, Spinal muscular atrophy with respiratory distress type 1 and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Multiple epidermal growth factor-like domains protein 10 |
|---|---|
| UniProt accession | Q96KG7 |
| Gene | MEGF10 |
| Organism | Homo sapiens |
| Length | 1140 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- MEGF10-related myopathy · score 0.78
- Spinal muscular atrophy with respiratory distress type 1 · score 0.77
- appendicular lean mass · score 0.37
- response to antipsychotic drug · score 0.25
- genetic disorder · score 0.19
- Helicobacter pylori infectious disease · score 0.17
- creatinine measurement · score 0.10
- neuroblastoma · score 0.07
- X-linked retinal dysplasia · score 0.06
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KG7-F1 | alphafold | PREDICTED | 70.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KG7.
Amino-acid sequence (1140 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MEGF10?
The strongest Open Targets associations for MEGF10 are MEGF10-related myopathy, Spinal muscular atrophy with respiratory distress type 1, appendicular lean mass, response to antipsychotic drug and genetic disorder.
How long is the MEGF10 protein?
The Homo sapiens MEGF10 protein (UniProt Q96KG7) is 1140 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KG7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KG7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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