N-terminal kinase-like protein (SCYL1)
Homo sapiens — UniProt Q96KG9
Data last refreshed: (UniProt release unknown)
Key facts
N-terminal kinase-like protein (SCYL1) is a protein from Homo sapiens identified by UniProt accession Q96KG9, 808 residues long. MolForge cross-references it against 0 known binders and 311 disease associations.
- UniProt accession: Q96KG9; gene symbol SCYL1.
- Organism: Homo sapiens.
- Length: 808 amino acids.
- Top disease associations (Open Targets): acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome, autosomal recessive cerebellar ataxia and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-terminal kinase-like protein |
|---|---|
| UniProt accession | Q96KG9 |
| Gene | SCYL1 |
| Organism | Homo sapiens |
| Length | 808 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (311)
Diseases linked to this target (Open Targets).
- acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome · score 0.75
- autosomal recessive cerebellar ataxia · score 0.55
- genetic disorder · score 0.52
- neuroinflammatory disorder · score 0.24
- Alzheimer disease · score 0.21
- Parkinson disease · score 0.21
- multiple sclerosis · score 0.21
- neurodegenerative disease · score 0.21
- lysosomal storage disease · score 0.21
- alkaline phosphatase measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KG9-F1 | alphafold | PREDICTED | 75.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KG9.
Amino-acid sequence (808 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SCYL1?
The strongest Open Targets associations for SCYL1 are acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome, autosomal recessive cerebellar ataxia, genetic disorder, neuroinflammatory disorder and Alzheimer disease.
How long is the SCYL1 protein?
The Homo sapiens SCYL1 protein (UniProt Q96KG9) is 808 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KG9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KG9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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