Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (COX4I2)
Homo sapiens — UniProt Q96KJ9
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (COX4I2) is a protein from Homo sapiens identified by UniProt accession Q96KJ9, 171 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q96KJ9; gene symbol COX4I2.
- Organism: Homo sapiens.
- Length: 171 amino acids.
- Top disease associations (Open Targets): pancreatic insufficiency-anemia-hyperostosis syndrome, Pancreatic insufficiency - anemia - hyperostosis and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial |
|---|---|
| UniProt accession | Q96KJ9 |
| Gene | COX4I2 |
| Organism | Homo sapiens |
| Length | 171 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- pancreatic insufficiency-anemia-hyperostosis syndrome · score 0.52
- Pancreatic insufficiency - anemia - hyperostosis · score 0.51
- heel bone mineral density · score 0.12
- refractive error measurement · score 0.06
- bronchiectasis with or without elevated sweat chloride 3 · score 0.06
- Young syndrome · score 0.05
- adrenal gland pheochromocytoma · score 0.05
- immunodeficiency 51 · score 0.04
- primary ciliary dyskinesia · score 0.04
- monocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KJ9-F1 | alphafold | PREDICTED | 79.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KJ9.
Amino-acid sequence (171 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COX4I2?
The strongest Open Targets associations for COX4I2 are pancreatic insufficiency-anemia-hyperostosis syndrome, Pancreatic insufficiency - anemia - hyperostosis, heel bone mineral density, refractive error measurement and bronchiectasis with or without elevated sweat chloride 3.
How long is the COX4I2 protein?
The Homo sapiens COX4I2 protein (UniProt Q96KJ9) is 171 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KJ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KJ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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