Histone H2A type 1-H (H2AC12)
Homo sapiens — UniProt Q96KK5
Data last refreshed: (UniProt release unknown)
Key facts
Histone H2A type 1-H (H2AC12) is a protein from Homo sapiens identified by UniProt accession Q96KK5, 128 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q96KK5; gene symbol H2AC12.
- Organism: Homo sapiens.
- Length: 128 amino acids.
- Top disease associations (Open Targets): viral disease, infectious disease and mineral metabolism disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone H2A type 1-H |
|---|---|
| UniProt accession | Q96KK5 |
| Gene | H2AC12 |
| Organism | Homo sapiens |
| Length | 128 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- viral disease · score 0.50
- infectious disease · score 0.50
- mineral metabolism disease · score 0.25
- schizophrenia · score 0.18
- intelligence · score 0.17
- hemoglobin measurement · score 0.16
- Red cell distribution width · score 0.14
- systolic blood pressure · score 0.13
- mean corpuscular volume · score 0.13
- depressive symptom measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KK5-F1 | alphafold | PREDICTED | 91.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KK5.
Amino-acid sequence (128 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with H2AC12?
The strongest Open Targets associations for H2AC12 are viral disease, infectious disease, mineral metabolism disease, schizophrenia and intelligence.
How long is the H2AC12 protein?
The Homo sapiens H2AC12 protein (UniProt Q96KK5) is 128 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KK5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KK5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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