Phospholipase A and acyltransferase 5 (PLAAT5)
Homo sapiens — UniProt Q96KN8
Data last refreshed: (UniProt release unknown)
Key facts
Phospholipase A and acyltransferase 5 (PLAAT5) is a protein from Homo sapiens identified by UniProt accession Q96KN8, 279 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q96KN8; gene symbol PLAAT5.
- Organism: Homo sapiens.
- Length: 279 amino acids.
- Top disease associations (Open Targets): hypertrophic cardiomyopathy, tri-iodothyronine/thyroxine ratio measurement and linear and whorled nevoid hypermelanosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholipase A and acyltransferase 5 |
|---|---|
| UniProt accession | Q96KN8 |
| Gene | PLAAT5 |
| Organism | Homo sapiens |
| Length | 279 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.15
- tri-iodothyronine/thyroxine ratio measurement · score 0.15
- linear and whorled nevoid hypermelanosis · score 0.03
- chronic myeloproliferative disorder · score 0.03
- eosinophil peroxidase deficiency · score 0.03
- neutropenia, severe congenital, 1, autosomal dominant · score 0.03
- Tetralogy of Fallot · score 0.02
- Down syndrome · score 0.02
- low density lipoprotein cholesterol measurement · score 0.02
- Ataxia-telangiectasia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KN8-F1 | alphafold | PREDICTED | 61.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KN8.
Amino-acid sequence (279 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLAAT5?
The strongest Open Targets associations for PLAAT5 are hypertrophic cardiomyopathy, tri-iodothyronine/thyroxine ratio measurement, linear and whorled nevoid hypermelanosis, chronic myeloproliferative disorder and eosinophil peroxidase deficiency.
How long is the PLAAT5 protein?
The Homo sapiens PLAAT5 protein (UniProt Q96KN8) is 279 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KN8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KN8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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