Gap junction delta-4 protein (GJD4)
Homo sapiens — UniProt Q96KN9
Data last refreshed: (UniProt release unknown)
Key facts
Gap junction delta-4 protein (GJD4) is a protein from Homo sapiens identified by UniProt accession Q96KN9, 370 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q96KN9; gene symbol GJD4.
- Organism: Homo sapiens.
- Length: 370 amino acids.
- Top disease associations (Open Targets): neurofibrillary tangles measurement, hemoglobin measurement and drug use measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gap junction delta-4 protein |
|---|---|
| UniProt accession | Q96KN9 |
| Gene | GJD4 |
| Organism | Homo sapiens |
| Length | 370 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.20
- hemoglobin measurement · score 0.19
- drug use measurement · score 0.16
- lung adenocarcinoma · score 0.14
- metabolite measurement · score 0.12
- optic cup area measurement · score 0.11
- PHF-tau measurement · score 0.11
- diastolic blood pressure · score 0.11
- smoking status measurement · score 0.11
- age at first facial hair · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KN9-F1 | alphafold | PREDICTED | 67.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KN9.
Amino-acid sequence (370 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GJD4?
The strongest Open Targets associations for GJD4 are neurofibrillary tangles measurement, hemoglobin measurement, drug use measurement, lung adenocarcinoma and metabolite measurement.
How long is the GJD4 protein?
The Homo sapiens GJD4 protein (UniProt Q96KN9) is 370 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KN9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KN9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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