Histone-lysine N-methyltransferase EHMT2 (EHMT2)
Homo sapiens — UniProt Q96KQ7
Data last refreshed: (UniProt release unknown)
Key facts
Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a protein from Homo sapiens identified by UniProt accession Q96KQ7, 1210 residues long. MolForge cross-references it against 5 known binders and 287 disease associations.
- UniProt accession: Q96KQ7; gene symbol EHMT2.
- Organism: Homo sapiens.
- Length: 1210 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, glioblastoma multiforme and low grade glioma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone-lysine N-methyltransferase EHMT2 |
|---|---|
| UniProt accession | Q96KQ7 |
| Gene | EHMT2 |
| Organism | Homo sapiens |
| Length | 1210 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (287)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- glioblastoma multiforme · score 0.28
- low grade glioma · score 0.27
- ovarian cancer · score 0.25
- blood protein measurement · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- smoking status measurement · score 0.22
- chronic lymphocytic leukemia · score 0.22
- systolic blood pressure · score 0.21
- lung adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KQ7-F1 | alphafold | PREDICTED | 68.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KQ7.
Amino-acid sequence (1210 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EHMT2?
The strongest Open Targets associations for EHMT2 are neurodegenerative disease, glioblastoma multiforme, low grade glioma, ovarian cancer and blood protein measurement.
How long is the EHMT2 protein?
The Homo sapiens EHMT2 protein (UniProt Q96KQ7) is 1210 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KQ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KQ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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