Zinc finger RNA-binding protein (ZFR)
Homo sapiens — UniProt Q96KR1
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger RNA-binding protein (ZFR) is a protein from Homo sapiens identified by UniProt accession Q96KR1, 1074 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q96KR1; gene symbol ZFR.
- Organism: Homo sapiens.
- Length: 1074 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, autosomal recessive spastic paraplegia type 71 and neurofibrillary tangles measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger RNA-binding protein |
|---|---|
| UniProt accession | Q96KR1 |
| Gene | ZFR |
| Organism | Homo sapiens |
| Length | 1074 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- autosomal recessive spastic paraplegia type 71 · score 0.37
- neurofibrillary tangles measurement · score 0.25
- pure or complex autosomal recessive spastic paraplegia · score 0.19
- hereditary spastic paraplegia · score 0.12
- Intellectual disability · score 0.12
- monocyte count · score 0.04
- pancreatic neoplasm · score 0.03
- reticulocyte count · score 0.03
- alcohol drinking · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KR1-F1 | alphafold | PREDICTED | 60.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KR1.
Amino-acid sequence (1074 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZFR?
The strongest Open Targets associations for ZFR are neurodegenerative disease, autosomal recessive spastic paraplegia type 71, neurofibrillary tangles measurement, pure or complex autosomal recessive spastic paraplegia and hereditary spastic paraplegia.
How long is the ZFR protein?
The Homo sapiens ZFR protein (UniProt Q96KR1) is 1074 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KR1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KR1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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