Phosphatase and actin regulator 3 (PHACTR3)
Homo sapiens — UniProt Q96KR7
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatase and actin regulator 3 (PHACTR3) is a protein from Homo sapiens identified by UniProt accession Q96KR7, 559 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q96KR7; gene symbol PHACTR3.
- Organism: Homo sapiens.
- Length: 559 amino acids.
- Top disease associations (Open Targets): mean platelet volume, self reported educational attainment and intelligence.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatase and actin regulator 3 |
|---|---|
| UniProt accession | Q96KR7 |
| Gene | PHACTR3 |
| Organism | Homo sapiens |
| Length | 559 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.45
- self reported educational attainment · score 0.43
- intelligence · score 0.38
- mathematical ability · score 0.37
- schizophrenia · score 0.34
- cognitive function measurement · score 0.31
- verbal-numerical reasoning measurement · score 0.29
- Abnormality of refraction · score 0.26
- rheumatoid arthritis · score 0.21
- metabolite measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96KR7-F1 | alphafold | PREDICTED | 62.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96KR7.
Amino-acid sequence (559 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHACTR3?
The strongest Open Targets associations for PHACTR3 are mean platelet volume, self reported educational attainment, intelligence, mathematical ability and schizophrenia.
How long is the PHACTR3 protein?
The Homo sapiens PHACTR3 protein (UniProt Q96KR7) is 559 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96KR7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96KR7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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