Mas-related G-protein coupled receptor member X4 (MRGPRX4)
Homo sapiens — UniProt Q96LA9
Data last refreshed: (UniProt release unknown)
Key facts
Mas-related G-protein coupled receptor member X4 (MRGPRX4) is a protein from Homo sapiens identified by UniProt accession Q96LA9, 322 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q96LA9; gene symbol MRGPRX4.
- Organism: Homo sapiens.
- Length: 322 amino acids.
- Top disease associations (Open Targets): Recurrent infection due to specific granule deficiency, neutrophil immunodeficiency syndrome and hepatorenocardiac degenerative fibrosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mas-related G-protein coupled receptor member X4 |
|---|---|
| UniProt accession | Q96LA9 |
| Gene | MRGPRX4 |
| Organism | Homo sapiens |
| Length | 322 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- Recurrent infection due to specific granule deficiency · score 0.04
- neutrophil immunodeficiency syndrome · score 0.04
- hepatorenocardiac degenerative fibrosis · score 0.04
- leukocyte count · score 0.04
- renal cysts and diabetes syndrome · score 0.04
- Mayer-Rokitansky-Kuster-Hauser syndrome · score 0.03
- renal hypodysplasia/aplasia 3 · score 0.03
- kidney disease · score 0.03
- immunodeficiency 81 · score 0.03
- 46,XX ovotesticular disorder of sex development · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96LA9-F1 | alphafold | PREDICTED | 81.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96LA9.
Amino-acid sequence (322 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRGPRX4?
The strongest Open Targets associations for MRGPRX4 are Recurrent infection due to specific granule deficiency, neutrophil immunodeficiency syndrome, hepatorenocardiac degenerative fibrosis, leukocyte count and renal cysts and diabetes syndrome.
How long is the MRGPRX4 protein?
The Homo sapiens MRGPRX4 protein (UniProt Q96LA9) is 322 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96LA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96LA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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