Dehydrogenase/reductase SDR family member 1 (DHRS1)

About Dehydrogenase/reductase SDR family member 1

Dehydrogenase/reductase SDR family member 1 (DHRS1) is a protein from Homo sapiens identified by UniProt accession Q96LJ7, 313 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Dehydrogenase/reductase SDR family member 1
UniProt accession	Q96LJ7
Gene	DHRS1
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

essential tremor · score 0.09
language impairment · score 0.08
Young adult-onset Parkinsonism · score 0.07
hepatocellular carcinoma · score 0.07
Hereditary late-onset Parkinson disease · score 0.07
X-linked dystonia-parkinsonism · score 0.06
Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.06
spinocerebellar ataxia type 15/16 · score 0.06
X-linked parkinsonism-spasticity syndrome · score 0.06
spinocerebellar ataxia type 20 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LJ7-F1	alphafold	PREDICTED	91.02	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96LJ7.

Amino-acid sequence (313 residues)

MAAPMNGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRVVAQE AQSLGGQCVP VVCDSSQESE VRSLFEQVDR EQQGRLDVLV NNAYAGVQTI LNTRNKAFWE TPASMWDDIN NVGLRGHYFC SVYGARLMVP AGQGLIVVIS SPGSLQYMFN VPYGVGKAAC DKLAADCAHE LRRHGVSCVS LWPGIVQTEL LKEHMAKEEV LQDPVLKQFK SAFSSAETTE LSGKCVVALA TDPNILSLSG KVLPSCDLAR RYGLRDVDGR PVQDYLSLSS VLSHVSGLGW LASYLPSFLR VPKWIIALYT SKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards