Centrosomal protein of 19 kDa (CEP19)
Homo sapiens — UniProt Q96LK0
Data last refreshed: (UniProt release unknown)
Key facts
Centrosomal protein of 19 kDa (CEP19) is a protein from Homo sapiens identified by UniProt accession Q96LK0, 163 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q96LK0; gene symbol CEP19.
- Organism: Homo sapiens.
- Length: 163 amino acids.
- Top disease associations (Open Targets): obesity due to CEP19 deficiency, morbid obesity and Bardet-Biedl syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centrosomal protein of 19 kDa |
|---|---|
| UniProt accession | Q96LK0 |
| Gene | CEP19 |
| Organism | Homo sapiens |
| Length | 163 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- obesity due to CEP19 deficiency · score 0.50
- morbid obesity · score 0.46
- Bardet-Biedl syndrome · score 0.45
- eosinophil count · score 0.08
- obesity due to melanocortin 4 receptor deficiency · score 0.07
- MODY · score 0.07
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
- LIPE-related familial partial lipodystrophy · score 0.04
- metabolic syndrome · score 0.04
- type 2 diabetes mellitus · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96LK0-F1 | alphafold | PREDICTED | 82.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96LK0.
Amino-acid sequence (163 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEP19?
The strongest Open Targets associations for CEP19 are obesity due to CEP19 deficiency, morbid obesity, Bardet-Biedl syndrome, eosinophil count and obesity due to melanocortin 4 receptor deficiency.
How long is the CEP19 protein?
The Homo sapiens CEP19 protein (UniProt Q96LK0) is 163 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96LK0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96LK0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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