Doublesex- and mab-3-related transcription factor B1 (DMRTB1)
Homo sapiens — UniProt Q96MA1
Data last refreshed: (UniProt release unknown)
Key facts
Doublesex- and mab-3-related transcription factor B1 (DMRTB1) is a protein from Homo sapiens identified by UniProt accession Q96MA1, 342 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.
- UniProt accession: Q96MA1; gene symbol DMRTB1.
- Organism: Homo sapiens.
- Length: 342 amino acids.
- Top disease associations (Open Targets): diffuse plaque measurement, adolescent idiopathic scoliosis and balding measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Doublesex- and mab-3-related transcription factor B1 |
|---|---|
| UniProt accession | Q96MA1 |
| Gene | DMRTB1 |
| Organism | Homo sapiens |
| Length | 342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (56)
Diseases linked to this target (Open Targets).
- diffuse plaque measurement · score 0.19
- adolescent idiopathic scoliosis · score 0.13
- balding measurement · score 0.09
- hair shape measurement · score 0.07
- azoospermia · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.07
- Testicular regression syndrome · score 0.06
- grip strength measurement · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96MA1-F1 | alphafold | PREDICTED | 59.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96MA1.
Amino-acid sequence (342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DMRTB1?
The strongest Open Targets associations for DMRTB1 are diffuse plaque measurement, adolescent idiopathic scoliosis, balding measurement, hair shape measurement and azoospermia.
How long is the DMRTB1 protein?
The Homo sapiens DMRTB1 protein (UniProt Q96MA1) is 342 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96MA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96MA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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