Non-structural maintenance of chromosomes element 3 homolog (NSMCE3)
Homo sapiens — UniProt Q96MG7
Data last refreshed: (UniProt release unknown)
Key facts
Non-structural maintenance of chromosomes element 3 homolog (NSMCE3) is a protein from Homo sapiens identified by UniProt accession Q96MG7, 304 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q96MG7; gene symbol NSMCE3.
- Organism: Homo sapiens.
- Length: 304 amino acids.
- Top disease associations (Open Targets): lung disease, immunodeficiency, and chromosome breakage syndrome;, ovarian cancer and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Non-structural maintenance of chromosomes element 3 homolog |
|---|---|
| UniProt accession | Q96MG7 |
| Gene | NSMCE3 |
| Organism | Homo sapiens |
| Length | 304 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- lung disease, immunodeficiency, and chromosome breakage syndrome; · score 0.67
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- esophageal cancer · score 0.14
- bone density · score 0.06
- urate measurement · score 0.06
- blood protein measurement · score 0.05
- skin pigmentation measurement · score 0.04
- hair colour measurement · score 0.04
- autism · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96MG7-F1 | alphafold | PREDICTED | 74.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96MG7.
Amino-acid sequence (304 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSMCE3?
The strongest Open Targets associations for NSMCE3 are lung disease, immunodeficiency, and chromosome breakage syndrome;, ovarian cancer, breast adenocarcinoma, esophageal cancer and bone density.
How long is the NSMCE3 protein?
The Homo sapiens NSMCE3 protein (UniProt Q96MG7) is 304 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96MG7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96MG7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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