Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)
Homo sapiens — UniProt Q96MG8
Data last refreshed: (UniProt release unknown)
Key facts
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) is a protein from Homo sapiens identified by UniProt accession Q96MG8, 357 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q96MG8; gene symbol PCMTD1.
- Organism: Homo sapiens.
- Length: 357 amino acids.
- Top disease associations (Open Targets): primary angle closure glaucoma, glaucoma and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 |
|---|---|
| UniProt accession | Q96MG8 |
| Gene | PCMTD1 |
| Organism | Homo sapiens |
| Length | 357 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- primary angle closure glaucoma · score 0.35
- glaucoma · score 0.27
- acute myeloid leukemia · score 0.26
- smoking status measurement · score 0.24
- peak expiratory flow · score 0.24
- sleep duration · score 0.24
- drug use measurement · score 0.20
- bulimia nervosa · score 0.18
- autism spectrum disorder · score 0.15
- obsessive-compulsive disorder · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96MG8-F1 | alphafold | PREDICTED | 84.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96MG8.
Amino-acid sequence (357 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCMTD1?
The strongest Open Targets associations for PCMTD1 are primary angle closure glaucoma, glaucoma, acute myeloid leukemia, smoking status measurement and peak expiratory flow.
How long is the PCMTD1 protein?
The Homo sapiens PCMTD1 protein (UniProt Q96MG8) is 357 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96MG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96MG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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