Palmitoyltransferase ZDHHC15 (ZDHHC15)
Homo sapiens — UniProt Q96MV8
Data last refreshed: (UniProt release unknown)
Key facts
Palmitoyltransferase ZDHHC15 (ZDHHC15) is a protein from Homo sapiens identified by UniProt accession Q96MV8, 337 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q96MV8; gene symbol ZDHHC15.
- Organism: Homo sapiens.
- Length: 337 amino acids.
- Top disease associations (Open Targets): X-linked non-syndromic intellectual disability, Inherited congenital spastic tetraplegia and oculocutaneous albinism type 1B.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Palmitoyltransferase ZDHHC15 |
|---|---|
| UniProt accession | Q96MV8 |
| Gene | ZDHHC15 |
| Organism | Homo sapiens |
| Length | 337 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.40
- Inherited congenital spastic tetraplegia · score 0.26
- oculocutaneous albinism type 1B · score 0.12
- isolated spina bifida · score 0.04
- anencephaly 1 · score 0.04
- spina bifida-hypospadias syndrome · score 0.04
- glioblastoma multiforme · score 0.03
- mean corpuscular volume · score 0.03
- neoplasm · score 0.02
- glioblastoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96MV8-F1 | alphafold | PREDICTED | 88.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96MV8.
Amino-acid sequence (337 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZDHHC15?
The strongest Open Targets associations for ZDHHC15 are X-linked non-syndromic intellectual disability, Inherited congenital spastic tetraplegia, oculocutaneous albinism type 1B, isolated spina bifida and anencephaly 1.
How long is the ZDHHC15 protein?
The Homo sapiens ZDHHC15 protein (UniProt Q96MV8) is 337 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96MV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96MV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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