Conserved oligomeric Golgi complex subunit 8 (COG8)
Homo sapiens — UniProt Q96MW5
Data last refreshed: (UniProt release unknown)
Key facts
Conserved oligomeric Golgi complex subunit 8 (COG8) is a protein from Homo sapiens identified by UniProt accession Q96MW5, 612 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q96MW5; gene symbol COG8.
- Organism: Homo sapiens.
- Length: 612 amino acids.
- Top disease associations (Open Targets): COG8-congenital disorder of glycosylation, congenital disorder of glycosylation and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 8 |
|---|---|
| UniProt accession | Q96MW5 |
| Gene | COG8 |
| Organism | Homo sapiens |
| Length | 612 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- COG8-congenital disorder of glycosylation · score 0.77
- congenital disorder of glycosylation · score 0.54
- neurodegenerative disease · score 0.43
- Parkinson disease · score 0.39
- multiple sclerosis · score 0.39
- Alzheimer disease · score 0.39
- lysosomal storage disease · score 0.39
- genetic disorder · score 0.19
- cerebellar hypoplasia-intellectual disability-congenital microcephaly-dystonia-anemia-growth retardation syndrome · score 0.12
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96MW5-F1 | alphafold | PREDICTED | 79.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96MW5.
Amino-acid sequence (612 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COG8?
The strongest Open Targets associations for COG8 are COG8-congenital disorder of glycosylation, congenital disorder of glycosylation, neurodegenerative disease, Parkinson disease and multiple sclerosis.
How long is the COG8 protein?
The Homo sapiens COG8 protein (UniProt Q96MW5) is 612 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96MW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96MW5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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