Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5)
Homo sapiens — UniProt Q96NI6
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5) is a protein from Homo sapiens identified by UniProt accession Q96NI6, 719 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.
- UniProt accession: Q96NI6; gene symbol LRFN5.
- Organism: Homo sapiens.
- Length: 719 amino acids.
- Top disease associations (Open Targets): unipolar depression, Myopia and major depressive disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and fibronectin type-III domain-containing protein 5 |
|---|---|
| UniProt accession | Q96NI6 |
| Gene | LRFN5 |
| Organism | Homo sapiens |
| Length | 719 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (96)
Diseases linked to this target (Open Targets).
- unipolar depression · score 0.46
- Myopia · score 0.44
- major depressive disorder · score 0.44
- age at onset · score 0.42
- lean body mass · score 0.42
- refractive error · score 0.39
- wellbeing measurement · score 0.38
- bipolar disorder · score 0.38
- diacylglycerol 38:3 measurement · score 0.32
- neurofibrillary tangles measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NI6-F1 | alphafold | PREDICTED | 73.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NI6.
Amino-acid sequence (719 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRFN5?
The strongest Open Targets associations for LRFN5 are unipolar depression, Myopia, major depressive disorder, age at onset and lean body mass.
How long is the LRFN5 protein?
The Homo sapiens LRFN5 protein (UniProt Q96NI6) is 719 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NI6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NI6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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