Transmembrane protein 74 (TMEM74)
Homo sapiens — UniProt Q96NL1
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 74 (TMEM74) is a protein from Homo sapiens identified by UniProt accession Q96NL1, 305 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q96NL1; gene symbol TMEM74.
- Organism: Homo sapiens.
- Length: 305 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, androgenetic alopecia and nose morphology measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 74 |
|---|---|
| UniProt accession | Q96NL1 |
| Gene | TMEM74 |
| Organism | Homo sapiens |
| Length | 305 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- androgenetic alopecia · score 0.29
- nose morphology measurement · score 0.26
- neoplasm · score 0.08
- forced expiratory volume · score 0.05
- 46,XY complete gonadal dysgenesis · score 0.05
- anxiety · score 0.05
- Testicular regression syndrome · score 0.05
- 46,XX ovotesticular disorder of sex development · score 0.04
- 46,XX testicular disorder of sex development · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NL1-F1 | alphafold | PREDICTED | 56.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NL1.
Amino-acid sequence (305 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM74?
The strongest Open Targets associations for TMEM74 are neurodegenerative disease, androgenetic alopecia, nose morphology measurement, neoplasm and forced expiratory volume.
How long is the TMEM74 protein?
The Homo sapiens TMEM74 protein (UniProt Q96NL1) is 305 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NL1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NL1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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