Cilia- and flagella-associated protein 418 (CFAP418)
Homo sapiens — UniProt Q96NL8
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 418 (CFAP418) is a protein from Homo sapiens identified by UniProt accession Q96NL8, 207 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q96NL8; gene symbol CFAP418.
- Organism: Homo sapiens.
- Length: 207 amino acids.
- Top disease associations (Open Targets): Cone rod dystrophy, retinitis pigmentosa and Bardet-Biedl syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 418 |
|---|---|
| UniProt accession | Q96NL8 |
| Gene | CFAP418 |
| Organism | Homo sapiens |
| Length | 207 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.73
- retinitis pigmentosa · score 0.62
- Bardet-Biedl syndrome · score 0.60
- body height · score 0.37
- autosomal recessive retinitis pigmentosa · score 0.33
- respiratory system disease · score 0.28
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.27
- sitting height measurement · score 0.26
- Retinal dystrophy · score 0.19
- PHF-tau measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NL8-F1 | alphafold | PREDICTED | 74.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NL8.
Amino-acid sequence (207 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP418?
The strongest Open Targets associations for CFAP418 are Cone rod dystrophy, retinitis pigmentosa, Bardet-Biedl syndrome, body height and autosomal recessive retinitis pigmentosa.
How long is the CFAP418 protein?
The Homo sapiens CFAP418 protein (UniProt Q96NL8) is 207 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NL8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NL8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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