Apoptosis-inducing factor 3 (AIFM3)
Homo sapiens — UniProt Q96NN9
Data last refreshed: (UniProt release unknown)
Key facts
Apoptosis-inducing factor 3 (AIFM3) is a protein from Homo sapiens identified by UniProt accession Q96NN9, 605 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q96NN9; gene symbol AIFM3.
- Organism: Homo sapiens.
- Length: 605 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, keratoconus and Testicular Germ Cell Tumor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Apoptosis-inducing factor 3 |
|---|---|
| UniProt accession | Q96NN9 |
| Gene | AIFM3 |
| Organism | Homo sapiens |
| Length | 605 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- keratoconus · score 0.23
- Testicular Germ Cell Tumor · score 0.12
- monocyte count · score 0.11
- lymphocyte count · score 0.10
- cholangiocarcinoma · score 0.09
- breast cancer · score 0.07
- MODY · score 0.06
- diabetes mellitus, permanent neonatal 4 · score 0.05
- diabetes mellitus, transient neonatal, 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NN9-F1 | alphafold | PREDICTED | 88.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NN9.
Amino-acid sequence (605 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AIFM3?
The strongest Open Targets associations for AIFM3 are neurodegenerative disease, keratoconus, Testicular Germ Cell Tumor, monocyte count and lymphocyte count.
How long is the AIFM3 protein?
The Homo sapiens AIFM3 protein (UniProt Q96NN9) is 605 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NN9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NN9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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