Patched domain-containing protein 1 (PTCHD1)
Homo sapiens — UniProt Q96NR3
Data last refreshed: (UniProt release unknown)
Key facts
Patched domain-containing protein 1 (PTCHD1) is a protein from Homo sapiens identified by UniProt accession Q96NR3, 888 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q96NR3; gene symbol PTCHD1.
- Organism: Homo sapiens.
- Length: 888 amino acids.
- Top disease associations (Open Targets): autism, genetic disorder and non-syndromic X-linked intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Patched domain-containing protein 1 |
|---|---|
| UniProt accession | Q96NR3 |
| Gene | PTCHD1 |
| Organism | Homo sapiens |
| Length | 888 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- autism · score 0.57
- genetic disorder · score 0.49
- non-syndromic X-linked intellectual disability · score 0.43
- Intellectual disability · score 0.34
- neurodegenerative disease · score 0.28
- Abnormal brain morphology · score 0.27
- autism spectrum disorder · score 0.26
- Rare genetic intellectual disability · score 0.26
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.18
- Neurodevelopmental disorder · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NR3-F1 | alphafold | PREDICTED | 84.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NR3.
Amino-acid sequence (888 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTCHD1?
The strongest Open Targets associations for PTCHD1 are autism, genetic disorder, non-syndromic X-linked intellectual disability, Intellectual disability and neurodegenerative disease.
How long is the PTCHD1 protein?
The Homo sapiens PTCHD1 protein (UniProt Q96NR3) is 888 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NR3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NR3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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