Vacuolar ATPase assembly protein VMA22 (VMA22)
Homo sapiens — UniProt Q96NT0
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar ATPase assembly protein VMA22 (VMA22) is a protein from Homo sapiens identified by UniProt accession Q96NT0, 180 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q96NT0; gene symbol VMA22.
- Organism: Homo sapiens.
- Length: 180 amino acids.
- Top disease associations (Open Targets): CCDC115-CDG, congenital disorder of glycosylation type II and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar ATPase assembly protein VMA22 |
|---|---|
| UniProt accession | Q96NT0 |
| Gene | VMA22 |
| Organism | Homo sapiens |
| Length | 180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- CCDC115-CDG · score 0.72
- congenital disorder of glycosylation type II · score 0.62
- neurodegenerative disease · score 0.47
- genetic disorder · score 0.19
- neoplasm · score 0.07
- cancer · score 0.04
- infection · score 0.02
- infect · score 0.02
- pachyonychia congenita · score 0.02
- chronic kidney disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NT0-F1 | alphafold | PREDICTED | 82.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NT0.
Amino-acid sequence (180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VMA22?
The strongest Open Targets associations for VMA22 are CCDC115-CDG, congenital disorder of glycosylation type II, neurodegenerative disease, genetic disorder and neoplasm.
How long is the VMA22 protein?
The Homo sapiens VMA22 protein (UniProt Q96NT0) is 180 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NT0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NT0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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