Dachshund homolog 2 (DACH2)
Homo sapiens — UniProt Q96NX9
Data last refreshed: (UniProt release unknown)
Key facts
Dachshund homolog 2 (DACH2) is a protein from Homo sapiens identified by UniProt accession Q96NX9, 599 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q96NX9; gene symbol DACH2.
- Organism: Homo sapiens.
- Length: 599 amino acids.
- Top disease associations (Open Targets): Premature ovarian insufficiency, body weight and idiopathic hypereosinophilic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dachshund homolog 2 |
|---|---|
| UniProt accession | Q96NX9 |
| Gene | DACH2 |
| Organism | Homo sapiens |
| Length | 599 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- Premature ovarian insufficiency · score 0.18
- body weight · score 0.04
- idiopathic hypereosinophilic syndrome · score 0.04
- immunodeficiency 75 · score 0.03
- serous adenocarcinoma · score 0.03
- severe combined immunodeficiency due to DCLRE1C deficiency · score 0.03
- body height · score 0.03
- body mass index · score 0.03
- Hepatic veno-occlusive disease - immunodeficiency · score 0.03
- Kimura disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NX9-F1 | alphafold | PREDICTED | 61.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NX9.
Amino-acid sequence (599 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DACH2?
The strongest Open Targets associations for DACH2 are Premature ovarian insufficiency, body weight, idiopathic hypereosinophilic syndrome, immunodeficiency 75 and serous adenocarcinoma.
How long is the DACH2 protein?
The Homo sapiens DACH2 protein (UniProt Q96NX9) is 599 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NX9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NX9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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