Nectin-4 (NECTIN4)
Homo sapiens — UniProt Q96NY8
Data last refreshed: (UniProt release unknown)
Key facts
Nectin-4 (NECTIN4) is a protein from Homo sapiens identified by UniProt accession Q96NY8, 510 residues long. MolForge cross-references it against 1 known binders and 163 disease associations.
- UniProt accession: Q96NY8; gene symbol NECTIN4.
- Organism: Homo sapiens.
- Length: 510 amino acids.
- Approved drugs acting on it (DrugCentral): Enfortumab Vedotin.
- Top disease associations (Open Targets): Ectodermal dysplasia - syndactyly syndrome, cancer and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nectin-4 |
|---|---|
| UniProt accession | Q96NY8 |
| Gene | NECTIN4 |
| Organism | Homo sapiens |
| Length | 510 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (163)
Diseases linked to this target (Open Targets).
- Ectodermal dysplasia - syndactyly syndrome · score 0.75
- cancer · score 0.47
- neoplasm · score 0.43
- benign urinary system neoplasm · score 0.37
- Transitional Cell Carcinoma · score 0.37
- urinary bladder cancer · score 0.36
- genetic disorder · score 0.16
- urothelial carcinoma · score 0.11
- triple-negative breast cancer · score 0.09
- renal pelvis/ureter urothelial carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NY8-F1 | alphafold | PREDICTED | 79.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NY8.
Amino-acid sequence (510 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target NECTIN4?
DrugCentral lists 1 approved drug whose mechanism of action is NECTIN4: Enfortumab Vedotin.
Which diseases are associated with NECTIN4?
The strongest Open Targets associations for NECTIN4 are Ectodermal dysplasia - syndactyly syndrome, cancer, neoplasm, benign urinary system neoplasm and Transitional Cell Carcinoma.
How long is the NECTIN4 protein?
The Homo sapiens NECTIN4 protein (UniProt Q96NY8) is 510 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NY8 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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