Structure-specific endonuclease subunit MUS81 (MUS81)
Homo sapiens — UniProt Q96NY9
Data last refreshed: (UniProt release unknown)
Key facts
Structure-specific endonuclease subunit MUS81 (MUS81) is a protein from Homo sapiens identified by UniProt accession Q96NY9, 551 residues long. MolForge cross-references it against 0 known binders and 224 disease associations.
- UniProt accession: Q96NY9; gene symbol MUS81.
- Organism: Homo sapiens.
- Length: 551 amino acids.
- Top disease associations (Open Targets): neutrophil count, monocyte count and cortical thickness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Structure-specific endonuclease subunit MUS81 |
|---|---|
| UniProt accession | Q96NY9 |
| Gene | MUS81 |
| Organism | Homo sapiens |
| Length | 551 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (224)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.31
- monocyte count · score 0.31
- cortical thickness · score 0.30
- platelet count · score 0.28
- platelet crit · score 0.27
- breast adenocarcinoma · score 0.25
- alkaline phosphatase measurement · score 0.22
- ovarian cancer · score 0.18
- heel bone mineral density · score 0.16
- vitamin D measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NY9-F1 | alphafold | PREDICTED | 77.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NY9.
Amino-acid sequence (551 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MUS81?
The strongest Open Targets associations for MUS81 are neutrophil count, monocyte count, cortical thickness, platelet count and platelet crit.
How long is the MUS81 protein?
The Homo sapiens MUS81 protein (UniProt Q96NY9) is 551 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NY9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NY9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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