Proline-rich acidic protein 1 (PRAP1)
Homo sapiens — UniProt Q96NZ9
Data last refreshed: (UniProt release unknown)
Key facts
Proline-rich acidic protein 1 (PRAP1) is a protein from Homo sapiens identified by UniProt accession Q96NZ9, 151 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q96NZ9; gene symbol PRAP1.
- Organism: Homo sapiens.
- Length: 151 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, colorectal carcinoma and Barrett's esophagus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proline-rich acidic protein 1 |
|---|---|
| UniProt accession | Q96NZ9 |
| Gene | PRAP1 |
| Organism | Homo sapiens |
| Length | 151 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- colorectal carcinoma · score 0.08
- Barrett's esophagus · score 0.05
- immune deficiency, familial variable · score 0.05
- hyper-IgM syndrome type 3 · score 0.04
- neoplasm · score 0.04
- Hodgkins lymphoma · score 0.04
- classic Hodgkin lymphoma · score 0.04
- hyper-IgM syndrome type 2 · score 0.04
- hyper-IgM syndrome type 5 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NZ9-F1 | alphafold | PREDICTED | 61.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NZ9.
Amino-acid sequence (151 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRAP1?
The strongest Open Targets associations for PRAP1 are neurodegenerative disease, colorectal carcinoma, Barrett's esophagus, immune deficiency, familial variable and hyper-IgM syndrome type 3.
How long is the PRAP1 protein?
The Homo sapiens PRAP1 protein (UniProt Q96NZ9) is 151 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NZ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NZ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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