Putative membrane-spanning 4-domains subfamily A member 4E (MS4A4E)
Homo sapiens — UniProt Q96PG1
Data last refreshed: (UniProt release unknown)
Key facts
Putative membrane-spanning 4-domains subfamily A member 4E (MS4A4E) is a protein from Homo sapiens identified by UniProt accession Q96PG1, 132 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q96PG1; gene symbol MS4A4E.
- Organism: Homo sapiens.
- Length: 132 amino acids.
- Top disease associations (Open Targets): bone quantitative ultrasound measurement, blood protein measurement and lipoprotein-associated phospholipase A(2) measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Putative membrane-spanning 4-domains subfamily A member 4E |
|---|---|
| UniProt accession | Q96PG1 |
| Gene | MS4A4E |
| Organism | Homo sapiens |
| Length | 132 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- bone quantitative ultrasound measurement · score 0.24
- blood protein measurement · score 0.23
- lipoprotein-associated phospholipase A(2) measurement · score 0.23
- soluble triggering receptor expressed on myeloid cells 2 measurement · score 0.16
- heel bone mineral density · score 0.14
- monocyte count · score 0.13
- neutrophil count · score 0.11
- bone density · score 0.10
- neutrophil percentage of leukocytes · score 0.10
- hypertension · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96PG1-F1 | alphafold | PREDICTED | 61.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96PG1.
Amino-acid sequence (132 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MS4A4E?
The strongest Open Targets associations for MS4A4E are bone quantitative ultrasound measurement, blood protein measurement, lipoprotein-associated phospholipase A(2) measurement, soluble triggering receptor expressed on myeloid cells 2 measurement and heel bone mineral density.
How long is the MS4A4E protein?
The Homo sapiens MS4A4E protein (UniProt Q96PG1) is 132 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96PG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96PG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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