Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Homo sapiens — UniProt Q96PG8
Data last refreshed: (UniProt release unknown)
Key facts
Bcl-2-binding component 3, isoforms 3/4 (BBC3) is a protein from Homo sapiens identified by UniProt accession Q96PG8, 261 residues long. MolForge cross-references it against 0 known binders and 307 disease associations.
- UniProt accession: Q96PG8; gene symbol BBC3.
- Organism: Homo sapiens.
- Length: 261 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, appendicular lean mass and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bcl-2-binding component 3, isoforms 3/4 |
|---|---|
| UniProt accession | Q96PG8 |
| Gene | BBC3 |
| Organism | Homo sapiens |
| Length | 261 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (307)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- appendicular lean mass · score 0.34
- body height · score 0.30
- breast adenocarcinoma · score 0.28
- esophageal cancer · score 0.28
- squamous cell lung carcinoma · score 0.27
- sex hormone-binding globulin measurement · score 0.26
- myeloid white cell count · score 0.26
- leukocyte count · score 0.25
- IGF-1 measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96PG8-F1 | alphafold | PREDICTED | 47.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96PG8.
Amino-acid sequence (261 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BBC3?
The strongest Open Targets associations for BBC3 are neurodegenerative disease, appendicular lean mass, body height, breast adenocarcinoma and esophageal cancer.
How long is the BBC3 protein?
The Homo sapiens BBC3 protein (UniProt Q96PG8) is 261 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96PG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96PG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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