Leukocyte receptor cluster member 8 (LENG8)
Homo sapiens — UniProt Q96PV6
Data last refreshed: (UniProt release unknown)
Key facts
Leukocyte receptor cluster member 8 (LENG8) is a protein from Homo sapiens identified by UniProt accession Q96PV6, 800 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q96PV6; gene symbol LENG8.
- Organism: Homo sapiens.
- Length: 800 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, self reported educational attainment and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leukocyte receptor cluster member 8 |
|---|---|
| UniProt accession | Q96PV6 |
| Gene | LENG8 |
| Organism | Homo sapiens |
| Length | 800 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- self reported educational attainment · score 0.27
- Red cell distribution width · score 0.10
- Obesity · score 0.02
- osteosarcoma · score 0.02
- IGA glomerulonephritis · score 0.01
- chronic kidney disease · score 0.01
- hepatitis B virus infection · score 0.01
- Pick disease · score 0.01
- breast carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96PV6-F1 | alphafold | PREDICTED | 55.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96PV6.
Amino-acid sequence (800 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LENG8?
The strongest Open Targets associations for LENG8 are neurodegenerative disease, self reported educational attainment, Red cell distribution width, Obesity and osteosarcoma.
How long is the LENG8 protein?
The Homo sapiens LENG8 protein (UniProt Q96PV6) is 800 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96PV6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96PV6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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