Cyclin-dependent kinase 15 (CDK15)

About Cyclin-dependent kinase 15

Cyclin-dependent kinase 15 (CDK15) is a protein from Homo sapiens identified by UniProt accession Q96Q40, 435 residues long. MolForge cross-references it against 3 known binders and 36 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 15
UniProt accession	Q96Q40
Gene	CDK15
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.31
BMI-adjusted hip circumference · score 0.28
bone quantitative ultrasound measurement · score 0.25
bone density · score 0.24
neuroinflammatory disorder · score 0.15
neutrophil count · score 0.14
leukocyte count · score 0.12
neoplasm · score 0.10
hair color · score 0.08
small cell lung carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96Q40-F1	alphafold	PREDICTED	72.35	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96Q40.

Amino-acid sequence (435 residues)

MGQELCAKTV QPGCSCYHCS EGGEAHSCRR SQPETTEAAF KLTDLKEASC SMTSFHPRGL QAARAQKFKS KRPRSNSDCF QEEDLRQGFQ WRKSLPFGAA SSYLNLEKLG EGSYATVYKG ISRINGQLVA LKVISMNAEE GVPFTAIREA SLLKGLKHAN IVLLHDIIHT KETLTFVFEY MHTDLAQYMS QHPGGLHPHN VRLFMFQLLR GLAYIHHQHV LHRDLKPQNL LISHLGELKL ADFGLARAKS IPSQTYSSEV VTLWYRPPDA LLGATEYSSE LDIWGAGCIF IEMFQGQPLF PGVSNILEQL EKIWEVLGVP TEDTWPGVSK LPNYNPEWFP LPTPRSLHVV WNRLGRVPEA EDLASQMLKG FPRDRVSAQE ALVHDYFSAL PSQLYQLPDE ESLFTVSGVR LKPEMCDLLA SYQKGHHPAQ FSKCW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards