Gasdermin-A (GSDMA)
Homo sapiens — UniProt Q96QA5
Data last refreshed: (UniProt release unknown)
Key facts
Gasdermin-A (GSDMA) is a protein from Homo sapiens identified by UniProt accession Q96QA5, 445 residues long. MolForge cross-references it against 0 known binders and 451 disease associations.
- UniProt accession: Q96QA5; gene symbol GSDMA.
- Organism: Homo sapiens.
- Length: 445 amino acids.
- Top disease associations (Open Targets): myeloid white cell count, leukocyte count and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gasdermin-A |
|---|---|
| UniProt accession | Q96QA5 |
| Gene | GSDMA |
| Organism | Homo sapiens |
| Length | 445 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (451)
Diseases linked to this target (Open Targets).
- myeloid white cell count · score 0.37
- leukocyte count · score 0.34
- neutrophil count · score 0.31
- asthma · score 0.30
- systemic scleroderma · score 0.27
- eosinophil count · score 0.27
- ulcerative colitis · score 0.26
- childhood onset asthma · score 0.26
- phosphatidylcholine measurement · score 0.23
- cystatin C measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QA5-F1 | alphafold | PREDICTED | 79.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QA5.
Amino-acid sequence (445 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GSDMA?
The strongest Open Targets associations for GSDMA are myeloid white cell count, leukocyte count, neutrophil count, asthma and systemic scleroderma.
How long is the GSDMA protein?
The Homo sapiens GSDMA protein (UniProt Q96QA5) is 445 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QA5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QA5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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