ATPase family AAA domain-containing protein 5 (ATAD5)

Homo sapiens — UniProt Q96QE3

Gene: ATAD5Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

ATPase family AAA domain-containing protein 5 (ATAD5) is a protein from Homo sapiens identified by UniProt accession Q96QE3, 1844 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.

UniProt accession: Q96QE3; gene symbol ATAD5.
Organism: Homo sapiens.
Length: 1844 amino acids.
Top disease associations (Open Targets): body height, lean body mass and body weights and measures.
3D structure: AlphaFold model available.

Target properties

Protein name	ATPase family AAA domain-containing protein 5
UniProt accession	Q96QE3
Gene	ATAD5
Organism	Homo sapiens
Length	1844 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (126)

Diseases linked to this target (Open Targets).

body height · score 0.42
lean body mass · score 0.40
body weights and measures · score 0.35
appendicular lean mass · score 0.35
mean corpuscular volume · score 0.35
BMI-adjusted waist circumference · score 0.35
breast carcinoma · score 0.34
body weight · score 0.33
fat body mass · score 0.32
forced expiratory volume · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96QE3-F1	alphafold	PREDICTED	46.52	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QE3.

Amino-acid sequence (1844 residues)

MVGVLAMAAA AAPPPVKDCE IEPCKKRKKD DDTSTCKTIT KYLSPLGKTR DRVFAPPKPS NILDYFRKTS PTNEKTQLGK ECKIKSPESV PVDSNKDCTT PLEMFSNVEF KKKRKRVNLS HQLNNIKTEN EAPIEISSDD SKEDYSLNND FVESSTSVLR YKKQVEVLAE NIQDTKSQPN TMTSLQNSKK VNPKQGTTKN DFKKLRKRKC RDVVDLSESL PLAEELNLLK KDGKDTKQME NTTSHANSRD NVTEAAQLND SIITVSYEEF LKSHKENKVE EIPDSTMSIC VPSETVDEIV KSGYISESEN SEISQQVRFK TVTVLAQVHP IPPKKTGKIP RIFLKQKQFE MENSLSDPEN EQTVQKRKSN VVIQEEELEL AVLEAGSSEA VKPKCTLEER QQFMKAFRQP ASDALKNGVK KSSDKQKDLN EKCLYEVGRD DNSKKIMENS GIQMVSKNGN LQLHTDKGSF LKEKNKKLKK KNKKTLDTGA IPGKNREGNT QKKETTFFLK EKQYQNRMSL RQRKTEFFKS STLFNNESLV YEDIANDDLL KVSSLCNNNK LSRKTSIPVK DIKLTQSKAE SEASLLNVST PKSTRRSGRI SSTPTTETIR GIDSDDVQDN SQLKASTQKA ANLSEKHSLY TAELITVPFD SESPIRMKFT RISTPKKSKK KSNKRSEKSE ATDGGFTSQI RKASNTSKNI SKAKQLIEKA KALHISRSKV TEEIAIPLRR SSRHQTLPER KKLSETEDSV IIIDSSPTAL KHPEKNQKKL QCLNDVLGKK LNTSTKNVPG KMKVAPLFLV RKAQKAADPV PSFDESSQDT SEKSQDCDVQ CKAKRDFLMS GLPDLLKRQI AKKAAALDVY NAVSTSFQRV VHVQQKDDGC CLWHLKPPSC PLLTKFKELN TKVIDLSKCG IALGEFSTLN SKLKSGNSAA VFMRTRKEFT EEVRNLLLEE IRWSNPEFSL KKYFPLLLKK QIEHQVLSSE CHSKQELEAD VSHKETKRKL VEAENSKSKR KKPNEYSKNL EKTNRKSEEL SKRNNSSGIK LDSSKDSGTE DMLWTEKYQP QTASELIGNE LAIKKLHSWL KDWKRRAELE ERQNLKGKRD EKHEDFSGGI DFKGSSDDEE ESRLCNTVLI TGPTGVGKTA AVYACAQELG FKIFEVNASS QRSGRQILSQ LKEATQSHQV DKQGVNSQKP CFFNSYYIGK SPKKISSPKK VVTSPRKVPP PSPKSSGPKR ALPPKTLANY FKVSPKPKNN EEIGMLLENN KGIKNSFEQK QITQTKSTNA TNSNVKDVGA EEPSRKNATS LILFEEVDVI FDEDAGFLNA IKTFMATTKR PVILTTSDPT FSLMFDGCFE EIKFSTPSLL NVASYLQMIC LTENFRTDVK DFVTLLTANT CDIRKSILYL QFWIRSGGGV LEERPLTLYR GNSRNVQLVC SEHGLDNKIY PKNTKKKRVD LPKCDSGCAE TLFGLKNIFS PSEDLFSFLK HKITMKEEWH KFIQLLTEFQ MRNVDFLYSN LEFILPLPVD TIPETKNFCG PSVTVDASAA TKSMNCLARK HSEREQPLKK SQKKKQKKTL VILDDSDLFD TDLDFPDQSI SLSSVSSSSN AEESKTGDEE SKARDKGNNP ETKKSIPCPP KTTAGKKCSA LVSHCLNSLS EFMDNMSFLD ALLTDVREQN KYGRNDFSWT NGKVTSGLCD EFSLESNDGW TSQSSGELKA AAEALSFTKC SSAISKALET LNSCKKLGRD PTNDLTFYVS QKRNNVYFSQ SAANLDNAWK RISVIKSVFS SRSLLYVGNR QASIIEYLPT LRNICKTEKL KEQGKSKRRF LHYFEGIHLD IPKETVNTLA ADFP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with ATAD5?

The strongest Open Targets associations for ATAD5 are body height, lean body mass, body weights and measures, appendicular lean mass and mean corpuscular volume.

How long is the ATAD5 protein?

The Homo sapiens ATAD5 protein (UniProt Q96QE3) is 1844 amino acids long.

Browse: Targets: A · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q96QE3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q96QE3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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