Leucine-rich repeat-containing protein 37B (LRRC37B)
Homo sapiens — UniProt Q96QE4
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 37B (LRRC37B) is a protein from Homo sapiens identified by UniProt accession Q96QE4, 947 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q96QE4; gene symbol LRRC37B.
- Organism: Homo sapiens.
- Length: 947 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, brain measurement and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 37B |
|---|---|
| UniProt accession | Q96QE4 |
| Gene | LRRC37B |
| Organism | Homo sapiens |
| Length | 947 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- brain measurement · score 0.19
- BMI-adjusted hip circumference · score 0.17
- FEV/FVC ratio · score 0.17
- body height · score 0.17
- forced expiratory volume · score 0.16
- vital capacity · score 0.13
- sitting height measurement · score 0.07
- white matter microstructure measurement · score 0.06
- refractive error · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QE4-F1 | alphafold | PREDICTED | 52.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QE4.
Amino-acid sequence (947 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC37B?
The strongest Open Targets associations for LRRC37B are neurodegenerative disease, brain measurement, BMI-adjusted hip circumference, FEV/FVC ratio and body height.
How long is the LRRC37B protein?
The Homo sapiens LRRC37B protein (UniProt Q96QE4) is 947 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QE4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QE4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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