Transcription elongation factor, mitochondrial (TEFM)
Homo sapiens — UniProt Q96QE5
Data last refreshed: (UniProt release unknown)
Key facts
Transcription elongation factor, mitochondrial (TEFM) is a protein from Homo sapiens identified by UniProt accession Q96QE5, 360 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q96QE5; gene symbol TEFM.
- Organism: Homo sapiens.
- Length: 360 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist circumference, neurodegenerative disease and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription elongation factor, mitochondrial |
|---|---|
| UniProt accession | Q96QE5 |
| Gene | TEFM |
| Organism | Homo sapiens |
| Length | 360 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.38
- neurodegenerative disease · score 0.37
- body height · score 0.37
- BMI-adjusted hip circumference · score 0.33
- lean body mass · score 0.27
- breast carcinoma · score 0.26
- erythrocyte count · score 0.25
- anthropometric measurement · score 0.25
- vital capacity · score 0.24
- body weight · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QE5-F1 | alphafold | PREDICTED | 81.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QE5.
Amino-acid sequence (360 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TEFM?
The strongest Open Targets associations for TEFM are BMI-adjusted waist circumference, neurodegenerative disease, body height, BMI-adjusted hip circumference and lean body mass.
How long is the TEFM protein?
The Homo sapiens TEFM protein (UniProt Q96QE5) is 360 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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