Sperm acrosome-associated protein 5 (SPACA5)
Homo sapiens — UniProt Q96QH8
Data last refreshed: (UniProt release unknown)
Key facts
Sperm acrosome-associated protein 5 (SPACA5) is a protein from Homo sapiens identified by UniProt accession Q96QH8, 159 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: Q96QH8; gene symbol SPACA5.
- Organism: Homo sapiens.
- Length: 159 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, tarsal-carpal coalition syndrome and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm acrosome-associated protein 5 |
|---|---|
| UniProt accession | Q96QH8 |
| Gene | SPACA5 |
| Organism | Homo sapiens |
| Length | 159 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- tarsal-carpal coalition syndrome · score 0.07
- neoplasm · score 0.05
- bladder transitional cell carcinoma · score 0.01
- cancer · score 0.00
- urinary bladder carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QH8-F1 | alphafold | PREDICTED | 90.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QH8.
Amino-acid sequence (159 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPACA5?
The strongest Open Targets associations for SPACA5 are neurodegenerative disease, tarsal-carpal coalition syndrome, neoplasm, bladder transitional cell carcinoma and cancer.
How long is the SPACA5 protein?
The Homo sapiens SPACA5 protein (UniProt Q96QH8) is 159 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QH8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QH8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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