Heparan sulfate glucosamine 3-O-sulfotransferase 6 (HS3ST6)
Homo sapiens — UniProt Q96QI5
Data last refreshed: (UniProt release unknown)
Key facts
Heparan sulfate glucosamine 3-O-sulfotransferase 6 (HS3ST6) is a protein from Homo sapiens identified by UniProt accession Q96QI5, 342 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q96QI5; gene symbol HS3ST6.
- Organism: Homo sapiens.
- Length: 342 amino acids.
- Top disease associations (Open Targets): esophageal adenocarcinoma, esophageal squamous cell carcinoma and psoriasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Heparan sulfate glucosamine 3-O-sulfotransferase 6 |
|---|---|
| UniProt accession | Q96QI5 |
| Gene | HS3ST6 |
| Organism | Homo sapiens |
| Length | 342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- esophageal adenocarcinoma · score 0.06
- esophageal squamous cell carcinoma · score 0.04
- psoriasis · score 0.03
- ulcerative colitis · score 0.02
- soluble triggering receptor expressed on myeloid cells 2 measurement · score 0.02
- colorectal cancer · score 0.02
- Crohn's disease · score 0.01
- hereditary angioedema · score 0.01
- nasopharyngeal neoplasm · score 0.01
- angioedema · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QI5-F1 | alphafold | PREDICTED | 82.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QI5.
Amino-acid sequence (342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HS3ST6?
The strongest Open Targets associations for HS3ST6 are esophageal adenocarcinoma, esophageal squamous cell carcinoma, psoriasis, ulcerative colitis and soluble triggering receptor expressed on myeloid cells 2 measurement.
How long is the HS3ST6 protein?
The Homo sapiens HS3ST6 protein (UniProt Q96QI5) is 342 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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