Vacuolar protein sorting-associated protein 35 (VPS35)
Homo sapiens — UniProt Q96QK1
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 35 (VPS35) is a protein from Homo sapiens identified by UniProt accession Q96QK1, 796 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.
- UniProt accession: Q96QK1; gene symbol VPS35.
- Organism: Homo sapiens.
- Length: 796 amino acids.
- Top disease associations (Open Targets): Hereditary late-onset Parkinson disease, Parkinson disease and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 35 |
|---|---|
| UniProt accession | Q96QK1 |
| Gene | VPS35 |
| Organism | Homo sapiens |
| Length | 796 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (157)
Diseases linked to this target (Open Targets).
- Hereditary late-onset Parkinson disease · score 0.67
- Parkinson disease · score 0.56
- neurodegenerative disease · score 0.55
- Parkinson disease, dominant · score 0.42
- Young adult-onset Parkinsonism · score 0.38
- late-onset Parkinson disease · score 0.38
- genetic disorder · score 0.33
- lysosomal storage disease · score 0.30
- age at menopause · score 0.10
- hepatocellular carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QK1-F1 | alphafold | PREDICTED | 91.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QK1.
Amino-acid sequence (796 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS35?
The strongest Open Targets associations for VPS35 are Hereditary late-onset Parkinson disease, Parkinson disease, neurodegenerative disease, Parkinson disease, dominant and Young adult-onset Parkinsonism.
How long is the VPS35 protein?
The Homo sapiens VPS35 protein (UniProt Q96QK1) is 796 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QK1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QK1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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