Alpha-protein kinase 1 (ALPK1)
Homo sapiens — UniProt Q96QP1
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-protein kinase 1 (ALPK1) is a protein from Homo sapiens identified by UniProt accession Q96QP1, 1244 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q96QP1; gene symbol ALPK1.
- Organism: Homo sapiens.
- Length: 1244 amino acids.
- Top disease associations (Open Targets): retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome, body mass index and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-protein kinase 1 |
|---|---|
| UniProt accession | Q96QP1 |
| Gene | ALPK1 |
| Organism | Homo sapiens |
| Length | 1244 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome · score 0.72
- body mass index · score 0.37
- body height · score 0.25
- neuritic plaque measurement · score 0.22
- pancreatic adenocarcinoma · score 0.21
- genetic disorder · score 0.19
- lean body mass · score 0.18
- waist circumference · score 0.17
- neurodegenerative disease · score 0.15
- protein measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QP1-F1 | alphafold | PREDICTED | 65.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QP1.
Amino-acid sequence (1244 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALPK1?
The strongest Open Targets associations for ALPK1 are retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome, body mass index, body height, neuritic plaque measurement and pancreatic adenocarcinoma.
How long is the ALPK1 protein?
The Homo sapiens ALPK1 protein (UniProt Q96QP1) is 1244 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QP1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QP1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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