Transcriptional regulator protein Pur-beta (PURB)
Homo sapiens — UniProt Q96QR8
Data last refreshed: (UniProt release unknown)
Key facts
Transcriptional regulator protein Pur-beta (PURB) is a protein from Homo sapiens identified by UniProt accession Q96QR8, 312 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q96QR8; gene symbol PURB.
- Organism: Homo sapiens.
- Length: 312 amino acids.
- Top disease associations (Open Targets): reaction time measurement, serum gamma-glutamyl transferase measurement and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcriptional regulator protein Pur-beta |
|---|---|
| UniProt accession | Q96QR8 |
| Gene | PURB |
| Organism | Homo sapiens |
| Length | 312 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- reaction time measurement · score 0.25
- serum gamma-glutamyl transferase measurement · score 0.20
- platelet component distribution width · score 0.20
- intelligence · score 0.18
- mean corpuscular volume · score 0.17
- platelet count · score 0.16
- Red cell distribution width · score 0.16
- reticulocyte count · score 0.14
- metabolite measurement · score 0.12
- mean corpuscular hemoglobin · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QR8-F1 | alphafold | PREDICTED | 72.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QR8.
Amino-acid sequence (312 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PURB?
The strongest Open Targets associations for PURB are reaction time measurement, serum gamma-glutamyl transferase measurement, platelet component distribution width, intelligence and mean corpuscular volume.
How long is the PURB protein?
The Homo sapiens PURB protein (UniProt Q96QR8) is 312 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QR8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QR8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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