Homeobox protein ARX (ARX)
Homo sapiens — UniProt Q96QS3
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein ARX (ARX) is a protein from Homo sapiens identified by UniProt accession Q96QS3, 562 residues long. MolForge cross-references it against 0 known binders and 292 disease associations.
- UniProt accession: Q96QS3; gene symbol ARX.
- Organism: Homo sapiens.
- Length: 562 amino acids.
- Top disease associations (Open Targets): X-linked lissencephaly with abnormal genitalia, developmental and epileptic encephalopathy, 1 and Partington syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein ARX |
|---|---|
| UniProt accession | Q96QS3 |
| Gene | ARX |
| Organism | Homo sapiens |
| Length | 562 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (292)
Diseases linked to this target (Open Targets).
- X-linked lissencephaly with abnormal genitalia · score 0.80
- developmental and epileptic encephalopathy, 1 · score 0.77
- Partington syndrome · score 0.77
- Spasticity - intellectual disability - X-linked epilepsy · score 0.76
- corpus callosum agenesis-abnormal genitalia syndrome · score 0.76
- intellectual disability, X-linked, with or without seizures, arx-related · score 0.73
- X-linked non-syndromic intellectual disability · score 0.72
- developmental and epileptic encephalopathy · score 0.70
- West syndrome · score 0.67
- infantile epileptic-dyskinetic encephalopathy · score 0.66
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QS3-F1 | alphafold | PREDICTED | 55.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QS3.
Amino-acid sequence (562 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARX?
The strongest Open Targets associations for ARX are X-linked lissencephaly with abnormal genitalia, developmental and epileptic encephalopathy, 1, Partington syndrome, Spasticity - intellectual disability - X-linked epilepsy and corpus callosum agenesis-abnormal genitalia syndrome.
How long is the ARX protein?
The Homo sapiens ARX protein (UniProt Q96QS3) is 562 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QS3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QS3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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