Transient receptor potential cation channel subfamily M member 7 (TRPM7)

Homo sapiens — UniProt Q96QT4

Gene: TRPM7Homo sapiensSwissProt reviewedIon channel

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a protein from Homo sapiens identified by UniProt accession Q96QT4, 1865 residues long. MolForge cross-references it against 0 known binders and 336 disease associations.

UniProt accession: Q96QT4; gene symbol TRPM7.
Organism: Homo sapiens.
Length: 1865 amino acids.
Target class: Ion channel.
Top disease associations (Open Targets): intestinal hypomagnesemia 1, autosomal dominant macrothrombocytopenia and systolic blood pressure.
3D structure: AlphaFold model available.

Target properties

Protein name	Transient receptor potential cation channel subfamily M member 7
UniProt accession	Q96QT4
Gene	TRPM7
Organism	Homo sapiens
Length	1865 residues
Molecular weight	—
EC numbers	—
Target class	Ion channel (inferred from UniProt keywords / EC)
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (336)

Diseases linked to this target (Open Targets).

intestinal hypomagnesemia 1 · score 0.42
autosomal dominant macrothrombocytopenia · score 0.37
systolic blood pressure · score 0.35
aspartate aminotransferase measurement · score 0.33
pulse pressure measurement · score 0.32
serum alanine aminotransferase measurement · score 0.32
neuroinflammatory disorder · score 0.31
self reported educational attainment · score 0.29
serum gamma-glutamyl transferase measurement · score 0.27
sitting height measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96QT4-F1	alphafold	PREDICTED	69.49	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QT4.

Amino-acid sequence (1865 residues)

MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ HACFTASLAM KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG SHSYRAKYVR LSYDTKPEVI LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV AKHVGDALKE HASRSSRKIC TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN LHSHFILVDD GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI KKTFNFGQNE ALHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL KGTNASAFDQ LILTLAWDRV DIAKNHVFVY GQQWLVGSLE QAMLDALVMD RVAFVKLLIE NGVSMHKFLT IPRLEELYNT KQGPTNPMLF HLVRDVKQGN LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL GGNNRRSGRN TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGKK KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA KALVACKIYR SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ DETMAMKLLT YELKNWSNST CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR LNMRKNSWYK VILSILVPPA ILLLEYKTKA EMSHIPQSQD AHQMTMDDSE NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP ITRKFYAFYH APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA NAYDNHVFVA GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM FYIVVIMALV LLSFGVPRKA ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA YEIDVCANDS VIPQICGPGT WLTPFLQAVY LFVQYIIMVN LLIAFFNNVY LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS LFCCICKRRK KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT AQKASEASKV HNEITRELSI SKHLAQNLID DGPVRPSVWK KHGVVNTLSS SLPQGDLESN NPFHCNILMK DDKDPQCNIF GQDLPAVPQR KEFNFPEAGS SSGALFPSAV SPPELRQRLH GVELLKIFNK NQKLGSSSTS IPHLSSPPTK FFVSTPSQPS CKSHLETGTK DQETVCSKAT EGDNTEFGAF VGHRDSMDLQ RFKETSNKIK ILSNNNTSEN TLKRVSSLAG FTDCHRTSIP VHSKQAEKIS RRPSTEDTHE VDSKAALIPD WLQDRPSNRE MPSEEGTLNG LTSPFKPAMD TNYYYSAVER NNLMRLSQSI PFTPVPPRGE PVTVYRLEES SPNILNNSMS SWSQLGLCAK IEFLSKEEMG GGLRRAVKVQ CTWSEHDILK SGHLYIIKSF LPEVVNTWSS IYKEDTVLHL CLREIQQQRA AQKLTFAFNQ MKPKSIPYSP RFLEVFLLYC HSAGQWFAVE ECMTGEFRKY NNNNGDEIIP TNTLEEIMLA FSHWTYEYTR GELLVLDLQG VGENLTDPSV IKAEEKRSCD MVFGPANLGE DAIKNFRAKH HCNSCCRKLK LPDLKRNDYT PDKIIFPQDE PSDLNLQPGN STKESESTNS VRLML

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with TRPM7?

The strongest Open Targets associations for TRPM7 are intestinal hypomagnesemia 1, autosomal dominant macrothrombocytopenia, systolic blood pressure, aspartate aminotransferase measurement and pulse pressure measurement.

How long is the TRPM7 protein?

The Homo sapiens TRPM7 protein (UniProt Q96QT4) is 1865 amino acids long.

Browse: Targets: T · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q96QT4 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q96QT4 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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