PHD finger protein 12 (PHF12)
Homo sapiens — UniProt Q96QT6
Data last refreshed: (UniProt release unknown)
Key facts
PHD finger protein 12 (PHF12) is a protein from Homo sapiens identified by UniProt accession Q96QT6, 1004 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q96QT6; gene symbol PHF12.
- Organism: Homo sapiens.
- Length: 1004 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, autism spectrum disorder and HbA1c measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PHD finger protein 12 |
|---|---|
| UniProt accession | Q96QT6 |
| Gene | PHF12 |
| Organism | Homo sapiens |
| Length | 1004 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- autism spectrum disorder · score 0.09
- HbA1c measurement · score 0.08
- neoplasm · score 0.07
- non-small cell lung carcinoma · score 0.07
- myeloid white cell count · score 0.05
- triple-negative breast cancer · score 0.04
- pulse pressure measurement · score 0.04
- cortical thickness · score 0.03
- smoking status measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QT6-F1 | alphafold | PREDICTED | 55.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QT6.
Amino-acid sequence (1004 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHF12?
The strongest Open Targets associations for PHF12 are neurodegenerative disease, autism spectrum disorder, HbA1c measurement, neoplasm and non-small cell lung carcinoma.
How long is the PHF12 protein?
The Homo sapiens PHF12 protein (UniProt Q96QT6) is 1004 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QT6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QT6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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