Hedgehog-interacting protein (HHIP)
Homo sapiens — UniProt Q96QV1
Data last refreshed: (UniProt release unknown)
Key facts
Hedgehog-interacting protein (HHIP) is a protein from Homo sapiens identified by UniProt accession Q96QV1, 700 residues long. MolForge cross-references it against 0 known binders and 262 disease associations.
- UniProt accession: Q96QV1; gene symbol HHIP.
- Organism: Homo sapiens.
- Length: 700 amino acids.
- Top disease associations (Open Targets): body height, BMI-adjusted waist circumference and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hedgehog-interacting protein |
|---|---|
| UniProt accession | Q96QV1 |
| Gene | HHIP |
| Organism | Homo sapiens |
| Length | 700 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (262)
Diseases linked to this target (Open Targets).
- body height · score 0.54
- BMI-adjusted waist circumference · score 0.53
- lean body mass · score 0.52
- vital capacity · score 0.50
- BMI-adjusted hip circumference · score 0.50
- forced expiratory volume · score 0.50
- BMI-adjusted waist-hip ratio · score 0.50
- FEV/FVC ratio · score 0.49
- birth weight · score 0.49
- sitting height measurement · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96QV1-F1 | alphafold | PREDICTED | 79.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96QV1.
Amino-acid sequence (700 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HHIP?
The strongest Open Targets associations for HHIP are body height, BMI-adjusted waist circumference, lean body mass, vital capacity and BMI-adjusted hip circumference.
How long is the HHIP protein?
The Homo sapiens HHIP protein (UniProt Q96QV1) is 700 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96QV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96QV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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