Pannexin-2 (PANX2)
Homo sapiens — UniProt Q96RD6
Data last refreshed: (UniProt release unknown)
Key facts
Pannexin-2 (PANX2) is a protein from Homo sapiens identified by UniProt accession Q96RD6, 677 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q96RD6; gene symbol PANX2.
- Organism: Homo sapiens.
- Length: 677 amino acids.
- Top disease associations (Open Targets): brain volume measurement, thyroid gland adenocarcinoma and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pannexin-2 |
|---|---|
| UniProt accession | Q96RD6 |
| Gene | PANX2 |
| Organism | Homo sapiens |
| Length | 677 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- brain volume measurement · score 0.30
- thyroid gland adenocarcinoma · score 0.18
- mean platelet volume · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- low density lipoprotein cholesterol measurement · score 0.05
- drug use measurement · score 0.05
- platelet component distribution width · score 0.05
- platelet count · score 0.05
- neoplasm · score 0.04
- plasminogen activator inhibitor 1 measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96RD6-F1 | alphafold | PREDICTED | 57.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96RD6.
Amino-acid sequence (677 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PANX2?
The strongest Open Targets associations for PANX2 are brain volume measurement, thyroid gland adenocarcinoma, mean platelet volume, nonpapillary renal cell carcinoma and low density lipoprotein cholesterol measurement.
How long is the PANX2 protein?
The Homo sapiens PANX2 protein (UniProt Q96RD6) is 677 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96RD6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96RD6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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