Pannexin-1 (PANX1)
Homo sapiens — UniProt Q96RD7
Data last refreshed: (UniProt release unknown)
Key facts
Pannexin-1 (PANX1) is a protein from Homo sapiens identified by UniProt accession Q96RD7, 426 residues long. MolForge cross-references it against 0 known binders and 269 disease associations.
- UniProt accession: Q96RD7; gene symbol PANX1.
- Organism: Homo sapiens.
- Length: 426 amino acids.
- Top disease associations (Open Targets): female infertility due to zona pellucida defect, serum alanine aminotransferase measurement and aspartate aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pannexin-1 |
|---|---|
| UniProt accession | Q96RD7 |
| Gene | PANX1 |
| Organism | Homo sapiens |
| Length | 426 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (269)
Diseases linked to this target (Open Targets).
- female infertility due to zona pellucida defect · score 0.48
- serum alanine aminotransferase measurement · score 0.47
- aspartate aminotransferase measurement · score 0.45
- Thyroid preparation use measurement · score 0.39
- female infertility due to oocyte meiotic arrest · score 0.37
- hypothyroidism · score 0.36
- mean corpuscular volume · score 0.31
- autoimmune thyroid disease · score 0.26
- HbA1c measurement · score 0.24
- lung adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96RD7-F1 | alphafold | PREDICTED | 74.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96RD7.
Amino-acid sequence (426 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PANX1?
The strongest Open Targets associations for PANX1 are female infertility due to zona pellucida defect, serum alanine aminotransferase measurement, aspartate aminotransferase measurement, Thyroid preparation use measurement and female infertility due to oocyte meiotic arrest.
How long is the PANX1 protein?
The Homo sapiens PANX1 protein (UniProt Q96RD7) is 426 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96RD7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96RD7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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