About Protein capicua homolog
Protein capicua homolog (CIC) is a protein
from Homo sapiens identified by UniProt accession
Q96RK0, 2517 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (204)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant 45 · score 0.72
- Intellectual disability · score 0.69
- genetic disorder · score 0.51
- neurodegenerative disease · score 0.47
- low grade glioma · score 0.46
- autosomal dominant non-syndromic intellectual disability · score 0.45
- oligodendroglioma · score 0.43
- anaplastic oligodendroglioma · score 0.43
- Neurodevelopmental disorder · score 0.41
- oligoastrocytoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q96RK0.
Amino-acid sequence (2517 residues)
MKPMKKACTG LSGPGSGSKS PPATRAKALR RRGAGEGDKP EEEDDEAQQP QPQSGPEEAE EGEEEEAERG PGAEGPPLEL HPGDPAPGPA EDPKGDGEAG RWEPSLSRKT ATFKSRAPKK KYVEEHGAGS SGVAGAPEER VRTPEEASGL GVPPRPPTST RSSSTDTASE HSADLEDEPA EACGPGPWPP GSTSGSYDLR QLRSQRVLAR RGDGLFLPAV VRQVRRSQDL GVQFPGDRAL TFYEGVPGAG VDVVLDATPP PGALVVGTAV CTCVEPGVAA YREGVVVEVA TKPAAYKVRL SPGPSSQPGL PGSLPQPPQP LHREPEEAVW VARSSLRLLR PPWEPETMLR KPPTGPEEEQ AEPGATLPPC PAALDPKQPE DAEVSKISFG GNLGTHCEEG EEKHPPALGT PALLPLPPPQ LLSPPPKSPA FVGPGRPGEQ PSPCQEGSQG GSRSSSVASL EKGTAPAARA RTPLTAAQQK YKKGDVVCTP SGIRKKFNGK QWRRLCSRDG CMKESQRRGY CSRHLSMRTK EMEGLADSGP GGAGRPAAVA AREGSTEFDW GDETSRDSEA SSVAARGDSR PRLVAPADLS RFEFDECEAA VMLVSLGSSR SGTPSFSPVS TQSPFSPAPS PSPSPLFGFR PANFSPINAS PVIQRTAVRS RHLSASTPKA GVLTPPDLGP HPPPPAPRER HSSGILPTFQ TNLTFTVPIS PGRRKTELLP HPGALGAPGA GGGGAAPDFP KSDSLDSGVD SVSHTPTPST PAGFRAVSPA VPFSRSRQPS PLLLLPPPAG LTSDPGPSVR RVPAVQRDSP VIVRNPDVPL PSKFPGEVGT AGEVRAGGPG RGCRETPVPP GVASGKPGLP PPLPAPVPIT VPPAAPTAVA QPMPAFGLAS SPFQPVAFHP SPAALLPVLV PSSYTSHPAP KKEVIMGRPG TVWTNVEPRS VAVFPWHSLV PFLAPSQPDP SVQPSEAQQP ASHPVASNQS KEPAESAAVA HERPPGGTGS ADPERPPGAT CPESPGPGPP HPLGVVESGK GPPPTTEEEA SGPPGEPRLD SETESDHDDA FLSIMSPEIQ LPLPPGKRRT QSLSALPKER DSSSEKDGRS PNKREKDHIR RPMNAFMIFS KRHRALVHQR HPNQDNRTVS KILGEWWYAL GPKEKQKYHD LAFQVKEAHF KAHPDWKWCN KDRKKSSSEA KPTSLGLAGG HKETRERSMS ETGTAAAPGV SSELLSVAAQ TLLSSDTKAP GSSSCGAERL HTVGGPGSAR PRAFSHSGVH SLDGGEVDSQ ALQELTQMVS GPASYSGPKP STQYGAPGPF AAPGEGGALA ATGRPPLLPT RASRSQRAAS EDMTSDEERM VICEEEGDDD VIADDGFGTT DIDLKCKERV TDSESGDSSG EDPEGNKGFG RKVFSPVIRS SFTHCRPPLD PEPPGPPDPP VAFGKGYGSA PSSSASSPAS SSASAATSFS LGSGTFKAQE SGQGSTAGPL RPPPPGAGGP ATPSKATRFL PMDPATFRRK RPESVGGLEP PGPSVIAAPP SGGGNILQTL VLPPNKEEQE GGGARVPSAP APSLAYGAPA APLSRPAATM VTNVVRPVSS TPVPIASKPF PTSGRAEASP NDTAGARTEM GTGSRVPGGS PLGVSLVYSD KKSAAATSPA PHLVAGPLLG TVGKAPATVT NLLVGTPGYG APAPPAVQFI AQGAPGGGTT AGSGAGAGSG PNGPVPLGIL QPGALGKAGG ITQVQYILPT LPQQLQVAPA PAPAPGTKAA APSGPAPTTS IRFTLPPGTS TNGKVLAATA PTPGIPILQS VPSAPPPKAQ SVSPVQAPPP GGSAQLLPGK VLVPLAAPSM SVRGGGAGQP LPLVSPPFSV PVQNGAQPPS KIIQLTPVPV STPSGLVPPL SPATLPGPTS QPQKVLLPSS TRITYVQSAG GHALPLGTSP ASSQAGTVTS YGPTSSVALG FTSLGPSGPA FVQPLLSAGQ APLLAPGQVG VSPVPSPQLP PACAAPGGPV ITAFYSGSPA PTSSAPLAQP SQAPPSLVYT VATSTTPPAA TILPKGPPAP ATATPAPTSP FPSATAGSMT YSLVAPKAQR PSPKAPQKVK AAIASIPVGS FEAGASGRPG PAPRQPLEPG PVREPTAPES ELEGQPTPPA PPPLPETWTP TARSSPPLPP PAEERTSAKG PETMASKFPS SSSDWRVPGQ GLENRGEPPT PPSPAPAPAV APGGSSESSS GRAAGDTPER KEAAGTGKKV KVRPPPLKKT FDSVDNRVLS EVDFEERFAE LPEFRPEEVL PSPTLQSLAT SPRAILGSYR KKRKNSTDLD SAPEDPTSPK RKMRRRSSCS SEPNTPKSAK CEGDIFTFDR TGTEAEDVLG ELEYDKVPYS SLRRTLDQRR ALVMQLFQDH GFFPSAQATA AFQARYADIF PSKVCLQLKI REVRQKIMQA ATPTEQPPGA EAPLPVPPPT GTAAAPAPTP SPAGGPDPTS PSSDSGTAQA APPLPPPPES GPGQPGWEGA PQPSPPPPGP STAATGR
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